the patient may also be considered at risk for breast cancer, in which case the methods provide prevention for cancer development.the patient may be afflicted with breast cancer, in which case the methods provide treatment for the disease.the present invention provides a method for treating breast cancer in a patient with the pharmaceutical composition described above.the pharmaceutical composition comprises a pharmaceutically acceptable carrier and at least one ofthe following: (1) a BCSM or a functional variant of a BCSM, (2) an antibody directed against a BCSM or its functional.the present invention provides a pharmaceutical composition for the treatment of breast cancer.the kit comprises at least one of the following (1) polynucleotide probe that specifically hybridizes to a polynucleotide transcribed from a BCSG, and (2) an antibody capable of immunospecific binding to a BCSM.the present invention provides a kit for diagnosing breast cancer.the present invention provides a method for diagnosing and monitoring breast cancer by comparing the expression levels of one or more BCSM in biological samples from a subject to control samples.the polynucleotides transcribed from and the polypeptides encoded by the BCSGs are designated as breast cancer specific markers (BCSM).the differentially expressed genes are designated as breast cancer specific genes (BCSG).the present invention discloses genes that are differentially expressed in breast cancer cell lines and breast cancer tissue samples as compared to control cell lines and normal tissue samples, the polynucleotides transcribed from these genes (SEQ ID NOS : 1 - 19), and the polypeptides encoded by these polynucleotides (SEQ ID NOS:20-38).the present invention provides compositions and methods for the diagnosis and treatment of breast cancer.Although advances have been made in detection and treatment ofthe disease, breast cancer remains the second leading cause of cancer-related deaths in women, affecting more than 180,000 women in the United States each year. BACKGROUND Breast cancer is the second leading cause of cancer-related deaths of women in North America.Such polynucleotides and polypeptides may be used for the detection and treatment of breast cancer.Such polynucleotides and polypeptides may be used for the detection and treatment of breast cancer. the invention specifically relates to breast cancer-specific genes (BCSG), and to polynucleotides transcribed from and polypeptides encoded by the BCSGs.the present invention relates generally to the detection and treatment of cancer, and in particular breast cancer.G01N2500/00- Screening for compounds of potential therapeutic value.G01N33/57415- Specifically defined cancers of breast.G01N33/57407- Specifically defined cancers.G01N33/574- Immunoassay Biospecific binding assay Materials therefor for cancer.G01N33/53- Immunoassay Biospecific binding assay Materials therefor.blood, urine Testing involving biospecific ligand binding methods Immunological testing G01N33/50- Chemical analysis of biological material, e.g.G01N33/00- Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00.G01N- INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES.Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.) Filing date Publication date Application filed by Georgetown University filed Critical Georgetown University Priority to AU2003217774A priority Critical patent/AU2003217774A1/en Publication of WO2003073911A2 publication Critical patent/WO2003073911A2/en Links Su Jun Yang Original Assignee Georgetown University Priority date (The priority date is an assumption and is not a legal conclusion. Google Patents Method and composition for detection and treatment of breast cancerÄownload PDF Info Publication number WO2003073911A2 WO2003073911A2 PCT/US2003/005984 US0305984W WO03073911A2 WO 2003073911 A2 WO2003073911 A2 WO 2003073911A2 US 0305984 W US0305984 W US 0305984W WO 03073911 A2 WO03073911 A2 WO 03073911A2 Authority WO WIPO (PCT) Prior art keywords breast cancer polypeptide ofthe seq acid sequence Prior art date Application number PCT/US2003/005984 Other languages French ( fr) Google Patents WO2003073911A2 - Method and composition for detection and treatment of breast cancer WO2003073911A2 - Method and composition for detection and treatment of breast cancer
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